La Amistad is located near the town of San Vito, a jumping off point for:

- Wilson Botanical Garden (Organization for Tropical Studies), San Vito, Costa Rica; a marvelous collection of living tropical plants and reference material

- The Osa Peninsula, Costa Rica, with the extraordinary lowland Corcovado National Park

- Golfito and the Golfo Dulce; home of beautiful beaches and a large population of dolphins

- David, Panama; a major transportation hub in Panama

- Bocas del Toro, Panama, with excellent coral reefs

- Volcán-Bambito, Panama; a five-star resort near Barú Volcano